ea0035p359 | Diabetes (epidemiology, pathophysiology) | ECE2014
Boucas Ana Paula
, Brondani Leticia
, Assman Tais
, Boelter Gabriela
, Canani Luis Henrique
, Crispim Daisy
Introduction: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. FNDC5 gene encodes a type I membrane protein that is processed proteolytically to form a newly identified hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene expression. Th...